Frontline vs Advantage: Which Is Better To Keep Your Dog Flea Free?

To sustain this free service, we receive affiliate commissions via some of our links. This doesn’t affect rankings. Our review process.

Frontline vs AdvantageFleas and ticks love to reside in pet’s fur (especially when it’s warm as they can’t live below freezing). Not only are these pesky parasites are a nuisance, they create health concerns too. Keep fleas and ticks from bothering your pup (and you) with a regular dose of medication. We’ve reviewed two of the most popular options on the market so you can compare and find which is a better fit your furry friend.

Frontline Plus

Frontline PlusView FrontLine Plus on Amazon

Frontline Plus, a Merial product, claims to kill 98-100% of fleas within 24 hours of topical application (though it doesn’t give a time frame for ticks). It not only treats adult fleas, but fleas in all stages, including eggs, larvae, flea allergy dermatitis, thereby breaking the flea cycle. It contains two tough killing ingredients:

  • Fipronil kills adult fleas and ticks by collecting in the oils of the hair follicle and releasing onto the skin and coat
  • (S)-methoprene kills flea eggs and larvae.

The formula also guards against sarcoptic mange and lice, is waterproof and protects your pup for up to 30 days. Plus, Frontline never expires so long as you store it according to package instructions. Frontline Plus is safe for puppies over eight weeks.

Popular Products

  • Orange – Dogs up to 22 lbs.- $25.99 for 3-Pack
  • Blue – Dogs 23-44 lbs. – $23.99 for 3-Pack
  • Purple – Dogs 45-88 lbs. –  for 3-Pack
  • Red – Dogs 89-132 lbs. –  $25.99

Advantage II

Advantage IIView Advantage II on Amazon

Advantage II, a topical product by Bayer, claims to kill fleas within 12 hours. It treats fleas in all stages (adults, eggs and larvae), as well as flea allergy dermatitis and lice. Unlike Frontline, it does not kill ticks. The two main ingredients are:

  • Imidacloprid attacks the flea’s nervous system and ultimately kills it
  • Pyriproxyfen is an insect growth regulator (IGR) that kills fleas in the immature stages of their life cycle by mimicking the juvenile growth hormone of fleas.

Both ingredients work together to break the flea cycle. Advantage II is also waterproof and lasts up to 30 days. The product never expires so long as you store it to package specifications and is safe for puppies seven weeks and older.

Popular Products


Both Frontline Plus and Advantage II are available in topical form and should be applied using the following steps:

  1. Open product carefully.
  2. Remove pet’s collar to aid in application.
  3. Part hair until the skin is showing on the nape of your dog’s neck, between the shoulder blades.
  4. Apply product on the neck (unless your dog is large or extra large, in which case you will repeat the part fur-and-apply method four times along your dogs back, finishing at the top of the tail).
  5. Though both products are waterproof, do not wash your dog for 24 hours after application to ensure full coverage has been reached.
  6. Wash your hands thoroughly after applying and discarding of the product.
  7. Give your pet a treat for being so good during their treatment!

Frontline vs Advantage: Which Is Better?

Frontline Plus is slightly cheaper than Advantage II and protects both against fleas (in their various stages) and ticks (whereas Advantage only treats fleas and is more expensive).

Advantage II clearly states that it kills fleas within 12 hours on its packaging, while Frontline Plus does not, but their website claims it terminates them in 24 hours.

What’s the verdict? While both products are similar in application and shelf life, Frontline Plus has the added value of killing both ticks and fleas. However, if you need more immediate results, you might be better off paying a little more for Advantage II.

Keep in mind that a product that works for one dog may not work as well for another. It is important to monitor your dog after application and also remember that these products work best as a preventative measure.

If you are interested in even more options, check out our in-depth flea and tick prevention reviews for some natural alternatives and other applications. If your dog already has fleas, you might also benefit from reading our article on Getting Rid of Fleas.

Have you ever used either of these products? Which do you prefer and why?

About The Author:

Sara is a writer for Canine Journal. She adores dogs and recently adopted a rescue pup named Beamer. Whole she may be adjusting to life with another being to care for, she needed no time to adjust to all the extra love.

We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to and affiliated sites.
Disclaimer: The information provided through this website should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

Disclaimer: This website contains reviews, opinions and information regarding products and services manufactured or provided by third parties. We are not responsible in any way for such products and services, and nothing contained here should be construed as a guarantee of the functionality, utility, safety or reliability of any product or services reviewed or discussed. Please follow the directions provided by the manufacturer or service provider when using any product or service reviewed or discussed on this website.

Notify of
Oldest Most voted
Inline Feedbacks
View all comments
September 1, 2020 6:22 am

The only thing that works for me is having a few chickens in the yard. They eat everything including fleas and ticks. My chickens were killed by a fox in the early summer this year and for the first time, my dog is bothered by fleas and ticks. I tried Advantage II on my dog. It didn’t affect the fleas at all! Short of getting more chickens, I don’t know what to do!

Wolfy barkbark
August 6, 2020 1:05 am

I used Advantage II on my 2 dogs a month ago. I only had 1 dose and I was short by a few pounds. It had very little effect but that could of been my shorting the dose I found some Frontline so I’m going to give it a go. I’m thinking if this fails then maybe it’s time to shave the dog’s fur off. I think my kid has fleas too. I’m going to try the Comfortis on her. Has anyone used the pill? I can’t really afford the vet at the moment with the virus and money is tight. I can buy the pill from Canada for $40 a dose. Then shipping, so it will be expensive especially after paying for shipping. I’m just a bit nervous being my dogs have never had it.

Apiffany Gaither Billings
August 6, 2020 10:39 pm
Reply to  Wolfy barkbark

Hey, I’m sorry to hear you’re dealing with fleas. They are definitely annoying and hard to deal with for anyone. Here are a couple of articles for some recommendations for a natural remedy as well as a strong defense. is also an option for purchasing medications and treatments for your pet. Good luck and I hope you find a remedy that helps soon!

Onig Elitneg
July 17, 2020 11:30 pm

Frontline, Advantage, k9 Adventix have not worked for close to a decade now. Seresto collar worked for a few years, but doesn’t anymore either. My dog can’t take the pill treatments, so I’m stuck with the topicals and they never ever work. I constantly treat the yard, the house, and our dog and it’s just a forever losing battle. Some Vets and the makers insist that they still work and blame it on improper use or not treating your yard and house at the same time, but it’s not that, they just don’t work. They use to work, they worked fabulously, now they don’t.

Apiffany Gaither Billings
July 20, 2020 9:54 am
Reply to  Onig Elitneg

Have you ever tried homemade remedies with essential oils or even Wondercide? We use essential oils on our dog’s collars and have had good luck with it for years.

December 28, 2019 4:36 am

We’ve been prescribed advantage by the vets for years and we have a raging flea infestation that is infecting all 3 of my animals, 2 cats and a dog, I’ve not only used advantage but also from the vets advice cleaned thoroughly through, used flea shampoo, sprays and house sprays etc and still no change, it’s just getting worse, I’ve spent hundreds now and the vets seem to think it’s a problem on my side! From the reviews it looks like the product went downhill in 2017, and that’s when my cats first showed signs of infestation, now it’s 2019 and still no change and also a puppy who’s now got them!! Definitely the product and not me, think I’ll try the frontline next!

Phyllis Agee
April 16, 2020 11:54 pm
Reply to  Kirsty

Dawn dish washing soap kills fleas so I bath my animals with it & I vacuumed & shampooed my carports with Dawn in the water reservoir & then I bought Adams carpet & Upholstery spray that kills fleas up to seven months & I also sprinkled my carpet with flea carpet powder & I also set out little dishes of Dawn dish washing soap with a desk light over each dish & at night it’s draws the fleas to the light & I will jump in the dish & they will die, but use Frontline Plus & treat your yard with flea & tick chemicals too‼️This is how I got rid of my infestation of fleas plus I bought flea collars also‼️

Julie frampton
December 15, 2019 7:14 pm

I have been using advantage for years I was going to change to frontline because I have two dog’s and a cat.and is very expensive being on a pension, and change too frontline, but after reading the comments about frontline, I think I will stick with advantage, why change when what you use works, though it’s more expensive, my pet’s are worth it,so I’m sticking to advantage

Karen Walker
August 24, 2019 7:19 am

We have been using Advocate which is expensive, is this the only one to protect against lung worm? Could we just use Frontline plus? We are pensioners with two dogs and find it a lot to find especially with the added cost of a vets prescription for Advocate.

June 4, 2019 12:03 pm

Adavantage II used to work great. But in late 2017 it seemed to be less effective. I suspect Bayer change to a cheaper formula. But I still bought it because I hoped I had only gotten some bad batches or maybe I didn’t apply it as well as I thought. So I bought more and was extremely careful about applying it to cats and it still didn’t work. So a month later I tried Frontline for the first time. It caused the fleas to aggravate the cats somehow but it did absolutely nothing.

And no, the fleas have not developed an immunity. That is an absurd excuse. Nor have the cats developed an immunity since a couple had it for the first time.

July 4, 2020 12:39 am
Reply to  Bob

I tried Frontline Plus which did absolutely nothing. I think I was feeding the fleas. The Frontline also caused my dogs to scratch constantly with irritation to skin. On a scale from 0 to 5, I would give it a Zero.

Deb M.
April 4, 2019 7:14 pm

I made the mistake of switching from Frontline Plus Orange to Advantage 1 one time. Living in the Southern US I was immediately sorry as ticks became a serious issue. I checked with my Vet and as soon as was safe I applied Frontline Plus and my problem disappeared within 2 days. I’ll never switch again, Frontline Plus has my vote for effectiveness against fleas, ticks and to date no side effects after 20+ years and use on 3 dogs.

March 22, 2019 9:29 am

I used Frontline until Bravecto became available her (South Africa). Frontline seemed to be 100% effective against fleas but did only work to a certain extent against ticks. Ticks would still attach and feed but were killed before being able to transfer the potentially lethal Biliary. I still had to search and remove attached ticks to prevent skin infections. Bravecto works on the tick’s CNS and causes the ticks to release and run thereby almost entirely eliminating the chance of skin infections.

February 7, 2020 12:17 pm
Reply to  Jurgen

I know this is an old post, but Bravecto can kill. There is a Facebook group of people who had problems with or lost their pet because of Bravecto, and it has 27,000 members, or it did the last time I saw it.

August 26, 2020 3:51 pm
Reply to  Alice

Frontline Plus worked on my small dog for years. He passed away 2 years ago – now I have 3 small dogs, and Frontline doesn’t work at all for them. I’ve tried several brands, and so far haven’t found one that works completely. Two of the dogs are sisters and they seem to have some relief from K9 Advantix. But the other girl is itching like crazy (and driving me crazy.). I bombed my house twice, sprayed my yard and beyond 3 or 4 times, powdered my entire house, and part of my hard with diatomaceous earth twice. I put flea collars on them, washed their bedding constantly, and cleaned out and sprayed my car 2-3 times. I did all of that in the proper sequence. It’s not killing the fleas, but my dogs and I are feeling a little queasy.

Jim G
February 20, 2019 1:06 am

I tried Frontline Plus on my Husky and it did absolutely nothing. Applied exactly according to directions for 3 months in a row. Time to try Advantage.

Paul Dixon
December 10, 2018 8:18 am

Frontline doesn’t work. Tried it with my cat and dog and didn’t work for either. Switched to Advantage and IT WORKS! Avoid Frontline, it smells very chemically bad and does nothing – the fleas are immune to it, just like mosquitos are getting immune to insect repellents and bacteria are getting immune to antibiotics. Advantage smells like marzipan (almonds) and stops my cat and dog itching within a day or two so I know it works so well!

July 4, 2020 12:45 am
Reply to  Paul Dixon

I also had no results with Frontline.

June 7, 2018 12:31 am

I have purchased advantage 11. And it did nothing for the fleas in fact I have spent hundreds of dollars on flea prevention on my pets and nothing works what happened to the original advantage I used it for years it worked great.

carolyn henley
January 8, 2017 10:07 pm

I used Advantage and found it had no effect on the fleas. I purchased early in the season when I noticed only 1 or 2 fleas on my dogs to catch them early. Now two weeks after using Advantage, and $180 poorer my dogs have a flea infestation. You should go onto the review page when you wrote the article, and see how many people are very dissatisfied with Advantage. Not good advice to give suggesting people throw money away on this product. I have not used Frontline in a long time, I did 10 years ago when I was vet nursing, and unless they have changed the ingredients it was ineffective then

July 4, 2020 12:49 am
Reply to  carolyn henley

I have tried many flea treatments including Frontline with no success at all. I don’t know what to do anymore.

Apiffany Gaither Billings
July 6, 2020 9:37 am
Reply to  Sharlene

Here are other options for flea prevention and treatment including homemade natural options.

August 26, 2020 3:56 pm

@ Apiffany GB.. Be honest now…Do any of the natural and/or homemade remedies work? I honestly hope so. I’ve tried many natural remedies for various things, and nothing ever seems to work. I am all for it, but I feel like it’s not real.

Apiffany Gaither Billings
August 27, 2020 10:45 am
Reply to  Julie

Honestly, I have five dogs and I have not used a chemically-based flea/tick preventative or treatment in the past 5 years. Instead, we use a diluted mixture of apple cider vinegar, citronella oil, and lemongrass oil. We also place lemongrass oil and citronella oil on their collars (which they do not wear very often and only outside). We also have a pet-safe pest control company that sprays our yard quarterly which probably helps as well. I cannot attest to homemade solutions working for every dog or for every situation, but I know for a fact it works for our dogs and has for years.

January 12, 2016 4:51 pm

I used Frontline all last year. It seems the fleas have become immune to the ingredients in the Frontline now. Making it not effective now.

June 9, 2016 6:38 pm
Reply to  K-9

Same problem here. Advantage II works great!