Clomipramine for Dogs with Canine Anxiety

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Sad dog in the dark: Clomipramine for DogsAs the owner of an anxious dog, I know all too well the challenges that come along with the canine manifestation of anxiety. For many dog owners the only remaining solution to offer their dog a “normal” life may be medication. Below we will take a look at one of the most commonly prescribed anti-anxiety medications for dogs – Clomipramine.

Identifying Canine Anxiety

One of the first steps when considering Clomipramine is being able to identify your dog’s symptoms. Unfortunately, dogs have a very limited means of communicating their symptoms and their needs with us and as a result it is important to track symptoms and their triggers. There are a number of key symptoms that can be exhibited with separation anxiety, generalized anxiety or stimulus specific anxiety.

Separation Anxiety

Separation anxiety is a common occurrence in dogs, this is because dogs are naturally pack animals and are not used to solitary life. Dogs with separation anxiety display symptoms of their anxiety when they are away from their bonded companions. These companions do not have to be human. In this type of situation a dog may exhibit the following behaviors or symptoms until they are reunited with their bonded companions: barking, whining, destructive behavior, escapist behavior, eliminating in the home, drooling excessively, shaking, pacing and howling.

Generalized Anxiety

Generalized anxiety is anxiety that occurs in any number of situations, it does not appear to be stimulus specific or limited to times of separation from the pack. Generalized anxiety can happen anywhere at any time and can be characterized by the same symptoms as separation anxiety.

Stimulus Specific Anxiety

Stimulus specific anxiety is anxiety that takes place in the presence of a particular stimulus such as thunder storms. In these dogs symptoms of anxiety are limited to times when this specific stimulus is present and disappear when the stimulus is not present. Symptoms of stimulus specific anxiety are the same as those present in separation anxiety.

What is Clomipramine?

Clomipramine is a medication prescribed to both people and canines for a variety of psychological ailments including: obsessive compulsive disorder, depression and anxiety. Clomipramine is a tricyclic anti-depressant that works by increasing levels of serotonin in the brain to balance out mood. One of the most significant uses of Clomipramine for dogs is to treat separation anxiety as well as aggression and obsessive compulsive actions.

Clomipramine is sold in capsules that come in a variety of doses. The dose that is right for your dog depends upon your dog’s size and breed as well as the severity of your dog’s symptoms. Your veterinarian will help you to determine which dose is right for your situation. As with any antidepressant it is important to wean your dog on to a full dose, beginning with the smallest dose possible and increasing that dose over long intervals. Slowly increasing dosage reduces the likelihood of any negative side effects. It is equally as important to wean a dog off Clomipramine as it is to wean them on to it, always check with your veterinarian before stopping any anti-depressant. Clomipramine is a prescription medication and requires a veterinary prescription in order to be purchased. It is important when purchasing this medication to do so from a reputable vendor in order to ensure a high quality medication.

Cautions with Clomipramine

There are a number of cautions to take note of when considering Clomipramine for your dog. As with humans, it is crucial that no dog that is currently or who has in the last 14 days taken a monoamine oxidase inhibitor take Clomipramine. Dogs that have used a Preventic tick collar in the last 14 days should also not be given Clomipramine. It is not unusual to see drowsiness or an increase in the effects of other medications when a dog has been given Clomipramine.

Some Side Effects Seen With Clomipramine

As with all drugs, Clomipramine has a list of side effects that you may or may not notice in your anxious dog. These side effects include:

  • Drowsiness
  • Dizziness
  • Constipation
  • Panting
  • Dry mouth
  • Dry eyes
  • Weakness
  • Mild agitation
  • Headache
  • Nausea
  • Loss of weight
  • Loss of appetite

Side effects are not limited to these symptoms and any effects that appear bothersome to either you or your pet should be discussed with a veterinarian.


If your dog exhibits any of the following symptoms after ingesting Clomipramine stop dosage and see your veterinarian or emergency veterinarian immediately:

  • Difficulty breathing
  • Hives
  • Irregular heartbeat
  • Difficulty urinating
  • Seizures
  • Fever accompanied by increased panting
  • Muscle stiffness
  • Muscle weakness
  • Swelling of the lips, tongue or face

When Not to Give Clomipramine

Clomipramine should not be given before Veterinarian advice if your pet has any of the following conditions:

  • Liver disease
  • Kidney disease
  • Asthma
  • Thyroid disease
  • Diabetes
  • Stomach or intestinal problems
  • Heart disease
  • High blood pressure
  • Seizures
  • Difficulty urinating
  • Glaucoma
  • Is pregnant or lactating

Other Names for Clomipramine

Like many drugs, there are a number of names by which Clomipramine can go by, these include: Anafanil (made by Novartis,) Clomicalm (made by Novartis) or the generic Clomipramine Hydrochloride. All of these drugs contain the same active ingredient but just like human medications they can include different inactive medications that may or may not affect how effective the medication is for your pet.

More Important Information about Clomipramine

Clomipramine is FDA approved for both human and veterinary use by prescription only. Currently Clomipramine is available in 25 mg, 50 mg and 75 mg capsules. The basic guideline for dosage of Clomipramine is 0.5 to 1.8 mg per pound of body weight to be administered every 24 hours. The exact dosage should be overseen by a veterinarian. While Clomipramine is sometimes prescribed for use in cats, it is not highly recommended because cats do tend to be sensitive to tricyclic antidepressants.

Missing a Dose of Clomipramine

If you miss a dose of your dog’s Clomipramine prescription, you should give the missed dose as soon as your remember UNLESS it is almost time for the next dose. If it is almost time for the next dose of your dog’s Clomipramine skip the missed dose. DO NOT EVER double the dose of the medication to make up for a missed dose.

Overdose of Clomipramine

If you suspect that your dog has overdosed on Clomipramine it is crucial to seek immediate emergency veterinarian help. Some of the symptoms to look out for in the case of Clomipramine overdose include: agitation, hallucination, drowsiness, confusion, seizures, low blood pressure, fatigue, dizziness and fainting.

My Story

To begin with, I would like to share a personal story of my ten-year old black Labrador Jet.

A Case of Canine Anxiety

Jet has always been an anxious dog without reason and I have always been an overprotective “mother” insisting that I did not want to drug my dog. As time wore on however, I had exhausted alternative options and after experiencing a house fire in 2011 Jet’s anxiety only became worse. I thought long and hard about our options and tried just about everything I could think of to lessen his anxiety but nothing even put a dent in his fear. Not only would Jet tremble and salivate none stop, but since the fire he had begun bolting for the door anytime anything beeped. While this development was an understandable one, it was certainly not the safest behavioral adaptation. This is when we spoke with our vet about medication.

Deciding on Clomipramine

Over the years I had researched numerous medications, weighing the pros and cons of each. However, at ten years old the potential for doing more harm than good to my senior dog with medication was now in the forefront of my mind. I brought up the idea of trying Clomipramine with our vet. I had heard more amazing “recovery” stories about this drug than many others and felt that it could be our saving grace. Our vet explained that she too had seen amazing results with the drug, but that we would have to medicate Jet every day consistently and potentially wait out a period of four to six weeks before seeing any results. I asked about side effects and anything else we should watch out for with Clomipramine in our senior dog and she stated that of all the clients she has on the drug she had seen very few reactions or side effects to speak of. The only “side note” she mentioned was that we would have to get Jet’s liver enzyme levels checked after a month to ensure that the drug was not harming his liver while it was being processed.

A Month after Beginning Clomipramine

A month after we begun a regular dosage of Clomipramine, Jet was taking one pill in the morning and one at night. I had yet to see any signs of improvement in his anxiety symptoms. We scheduled a blood draw with our vet and on the same day picked up Frontline Plus flea and tick preventative. Jet has been on Frontline since he was a youngster but this time something went wrong. Our vet called it an “unseen reaction between Clomipramine and Frontline Plus.” A reaction that overnight turned the application site on his neck blood-red and caused itching and hair loss in significant clumps. Upon treatment our vet gave us the option to continue Clomipramine for another few weeks to see if we saw any improvement in anxiety, I rejected. We are now weaning Jet off Clomipramine and treating the freshly shaved patch on the back of his neck with antibiotics and steroids. Our search for the perfect anti-anxiety solution is still underway.

Is Our Story Typical?

The tricky thing with any prescription medication is that there are a number of factors that play in to its effectiveness. Individual body chemistry, severity of anxiety or depression, age and other medications currently being given, all play a part in the effectiveness of a medication. There is no “typical” result and just because our story was an unsuccessful one does not mean that yours will be too.

Natural Alternatives to Clomipramine for Dogs

Clomipramine is not the only available solution for anxious dogs; there are a number of alternatives to consider before deciding to administer this prescription medication.

Thunder Shirt

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Thundershirt Dog JacketThundershirt Dog Jacket

Just as some babies respond well to swaddling, some dogs respond well to the feeling of being swaddled as well. The thunder shirt is a shirt that slightly compresses the dog to make them feel safer during times of extreme stress such as during a thunderstorm. The Thunder Shirt comes in a variety of sizes and wraps around the dog using Velcro closures. The Thunder Shirt has an 80% improvement in anxiety rate among dogs that have tried it and it comes with a money back guarantee. If the Thunder Shirt does not improve your dog’s anxiety, Thunder Shirt will refund your money completely with no questions asked.

Learn more about ThunderShirt’s in this video:

Behavioral Intervention

Behavioral intervention is available in a number of forms for anxious dogs. Most commonly “Fearful Fido’s” classes are offered which give pet owners the opportunity to learn behavioral modification techniques in small groups. Other pet owners opt to hire one on one trainers who can devote more time to their anxious dog’s specific needs. Behavioral intervention is generally the preferred method of treatment for canine anxiety because it is drug free and teaches a dog the techniques to cope with anxious situations rather than treating symptoms of anxiety. Behavioral intervention is commonly supplemented with holistic anxiety treatment methods.

Holistic or “Natural” Anti-Anxiety Treatments

Holistic or “natural” anti-anxiety treatments depend upon herbal supplementation in order to treat symptoms of anxiety. This method of anxiety treatment is often paired with behavioral therapy as it can lessen the severity of symptoms in order to focus a dog on learning new coping techniques. Common types of holistic or “natural” anti-anxiety treatments include: Shen Calmer, DAP or Dog Appeasing Pheromone collars and diffusers, essential lavender oil, flower essences, Chinese herbal blend medications, Composure supplemental chews and others. Depending upon your dog’s specific levels of anxiety you may or may not find these types of treatments useful. It is important to check with a veterinarian before administering any of these medications because as with humans, even herbal medications can interfere with prescription medications or existing health conditions.

When to Consider Medication for Your Anxious Dog

Considering medication for any pet can be difficult because it is impossible to know just how your pet is feeling while on medication. It is additionally concerning to know that many prescription medications come with serious side effects that require continuous monitoring. For some pet owners however, anxiety medication may be the only solution to give their pet a healthy life. In the event that all other anti-anxiety medications have been tried to no avail, medication may be the only remaining option.

In the event that your anxious dog has shown no improvement with other treatments for anxiety, it is important to research all available anxiety medications such as Clomipramine, and to speak with your dog’s veterinarian to find the right match for your dog. Some things to consider when researching medications for your dog’s anxiety include: the severity of your dog’s anxiety, your dog’s age, your dog’s current health condition, any existing medications, the cost of medication, the potential side effects of a medication and how long a particular medication has been on the market. All of these things will help you to get a picture of which anti-anxiety medication might be the right choice for your dog.

Why We Chose Clomipramine

At ten years old Jet is considered to be a “senior” which means that his bodily system may not be as tolerant of medications as that of a younger dog. In addition to his age, recent events in his life (our home fire) resulted in a significant worsening of his symptoms which drove me to seeking out an anxiety solution that would allow him to be comfortable in his own home. Over the years I have worked with Jet on behavioral modification as well as tried a variety of herbal and natural anxiety solutions, all to no avail. Our final option prior to medication was the Thunder Shirt and unfortunately for Jet, the shirt did not work for him either. It was at this point, when my dog was running for the door every time the toaster beeped, cowering and trembling every time he set foot on a wooden floor and drooling and pacing obsessively when I left the house that I decided to consider Clomipramine. Unfortunately for us, Clomipramine showed no improvement in Jet’s anxiety over the first four weeks. Our vet asked me to consider another few weeks on the drug to see if he received any relief; however, after one significant reaction between Clomipramine and Frontline I decided that it was time to wean him off the drug. Some professionals might say that in cases of severe anxiety like Jet’s that he is just “too far gone” to be helped. As a responsible pet parent however, I continue to seek a canine anxiety solution that offers my senior dog a degree of comfort and relief.

Just because Clomipramine didn’t do what I hoped it would for Jet, doesn’t mean that it won’t show some improvement in your anxious dog’s symptoms. Clomipramine has a history of high relief rates, a low incidence of side effects and is an affordable option for those considering anti-anxiety medication.

Has your dog taken Clomipramine?

Disclaimer: Information regarding insurance company offerings, pricing and other contract details are subject to change by the insurance company at any time and are not under the control of this website. Information published on this website is intended for reference use only. Please review your policy carefully before signing up for a new pet health insurance contract or any other contract as your unique circumstances will differ from those of others who may be used for example purposes in this article.

Amy grew up in England and in the early 1990’s moved to North Carolina where she completed a bachelors degree in Psychology in 2001. Amy’s personal interest in writing was sparked by her love of reading fiction and her creative writing hobby. Amy is currently self employed as a freelance writer and web designer. When she is not working Amy can be found curled up with a good book and her black Labrador, Jet.

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5 Comments on "Clomipramine for Dogs with Canine Anxiety"

Anne Harrison
Anne Harrison
It does say on the “Cautions with Clomipramine” section that dogs that have used a Preventic tick collar in the last 14 days should also not be given Clomipramine. Maybe that’s why your dog got the rash? I asked my vet to prescribe this drug and send it to Costco for me to pick up. It’s way cheaper that way!
Lisa F
Lisa F
We’ve just started our 5.5 year old St. Bernard on this. After years of trying all of the different remedies, including: rescue remedy, canine composure, training, thunder jacket, touch (which I highly recommend, BTW), we finally realized our big guy needed some help.

His problem is anxiety/OCD. He just cannot settle; he paces, pants, whines and obsessively chews at his legs and tail, ripping chunks of fur out. We’ve done full blood panels, allergy tests (he’s off wheat now) and x-rays to ensure it was nothing physical.

Our vet prescribed 200 mg/daily (he’s 140 pounds) and also gave us a prescription for Xanax on an as-needed basis. Maybe it’s wishful thinking, but after a week, he is noticeably calmer and more relaxed. Can’t say enough good about this one!

ChaCubed - one of 65,844,954
ChaCubed - one of 65,844,954
Thank you for a comprehensive article which included your experience.

My dog has separation anxiety, but he only barks when I leave and when he hears me return (I know because I’ve parked my car down the street, several times, and snuck back to listen). Except for some scratching on the door when he hears me, there’s no destructive activity when I’m gone.

But he did have anxiety about loud sounds and unusual lights, like fireworks, thunderstorms, and unexpected sounds that startled him while we walked, and ThunderShirt not only stopped his reaction while wearing it; after putting it on during stressful situations a few times, the stress reaction stopped even without the ThunderShirt – except for startling loud noises while walking on the street, which quickly passes. I live on a lake with a lot of 4th of July fireworks, and he sits in my lap while I’m watching them from the porch, without the ThunderShirt, and without any signs of stress.

I have never tried the Thundershirt for separation anxiety, because when I come home, he’s panting, and I don’t know if he’s been panting all along, or if it starts when he hears the sound of the car when I come home, so I don’t want to risk his overheating in a ThunderShirt when I’m not there. But … a part of me also thinks I should get a child cam to see and hear what his level of stress is when I’m not there.

Kimberly Alt
Kimberly Alt
Getting some type of camera may not be a bad idea. This will give you a better understanding of what your dog experiences throughout the day so you can help him more. We’ve written an article on pet cams, Take a look and feel free to ask any questions you may have!
Amy so sorry to hear your dog is suffering from depression and that this medication didn’t help Jet’s sad symptoms. My dog has also been sluggish lately but am going to try some of these natural remedies first before going down the medication route. Doggy depression is never easy so stay strong and hopefully our puts can have pep in their step soon.

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