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Mastiff Mixes: 20 Different Gentle Giant Crossbreeds You’ll Love


Last Updated: June 6, 2023 | 15 min read | 9 Comments

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The Mastiff, also known as the English Mastiff, is a gorgeous, gentle giant. His breed has experienced quite a turbulent history, and is one of the oldest dog breeds around. Not only were they used as entertainment in cruel blood sports against other immense beasts, but they were also used in battles against mankind. During their travels, they mated with local dogs and are believed to be the forefather of Saint Bernard, Rottweiler, and Dogue de Bordeaux, amongst many others. A Mastiff mix can be a very agreeable and unforgettable pup.

The Mastiff is described as courageous, and he makes a great watchdog. He is not one to be messed with, but he is rarely aggressive and would much rather stand his ground. He is a well-balanced and friendly dog who really is a gentle giant in the truest sense. However, he is a lazy dude who will try to convince you that climbing onto the sofa is enough exercise, so a strong-willed owner is much needed here. He is super affectionate and a big softy.

All of these adorable characteristics can be found in all of his Mastiff mixed-breed puppies. Let’s jump in and meet 20 of our favorite Matiff mixes. Maybe one of these big softies is just right for your family.

The mighty Mastiff first came to America after World War II, and ever since then, his popularity has soared. In 2022, the American Kennel Club ranked him as America’s 37th most popular dog breed. According to their breed standard, male Mastiffs reach heights of 30 inches plus and weigh between 160 and 230 pounds, and female Mastiffs measure 27 1/2 inches plus and weigh between 120 and 170 pounds. However, they are known to be much larger than this, and in the 1989 Guinness Book of Records, a Mastiff named Zorba became the largest dog on the planet, weighing in at 323 pounds, and this record remains undefeated.

So, if you are thinking about welcoming a Mastiff mix into your home, you need to be prepared for his size, feed him mastiff-appropriate food, and just in case he is the next Zorba, you need a lot of spare room or a really huge dog crate.

Mastiff Mixed Breeds

So now you know what to expect from the Mastiff, but what can you really expect from his mixed pups? Well, nothing is guaranteed when it comes to mixed pooches, so you need to be a little open-minded. All you need to know is that you like every aspect of both of his parents, and if you don’t, then you should move on to the next mix.

Below we have selected 15 of the most adorable mixes, with some of the other breeds being very popular and some you may never have heard of. They are all proving to be some of the most popular Mastiff mixes out there, and there is undoubtedly a mix out there for everyone.

If you are not certain of your dog’s genetic makeup, you can use an at-home DNA test kit to find out.

Bernese Mountain Dog Mastiff Mix

Bernese Mastiff Mix

While this mix can get mistaken for a fluffy Mastiff or even a Saint Bernard, the Mastiff Bernese Mountain dog mix is a unique mix that will love your family and be friendly with just about anyone.  They can be on the larger side and are likely to inherit the longer hair of the Bernese, given that the English Mastiff has a long-haired recessive gene as it is.

The Bernese Mountain Dog is usually an extremely friendly breed; temperament-wise, they are usually pretty mellow.  They can be stubborn at times, though, and if your mix inherits some Mastiff traits, you could have a headstrong pup on your hands.  This means experience handling larger stubborn breeds is usually recommended.

Boxmas: Boxer Mastiff Mix

Boxer Mastiff Mix

He is a muscular and stocky guy who will weigh 75 pounds and upwards, and he will measure up to 30 inches in height. Typically, he will inherit the Mastiff frame but with the Boxer head. His coat is short and smooth, and he will sport the black, brown and brindle coloring, with a splash of white across his body. He has a square head with a fleshy square nose, and you can expect him to be a drooler too!

The Boxmas is an energetic, playful guy, and this canine is a comical soul whose aim in life is to make everyone laugh. He seems to have little coordination, so you can expect him to walk into things and fall over his own paws. Because of his boisterous energy, and much larger size, he should be placed in a larger home with older children. He is so excitable that he might not have time for training, and combined with the Mastiff’s stubbornness, you might never finish a training session! To learn more about this mix, check out our Boxmas breed profile.

Daniff: Great Dane Mastiff Mix

Mastiff Great Dane Mix

The Daniff is one of the largest and tallest on this list and is also often compared to the Mastiff due to their size.  You can expect this mix to reach heights of 30 inches plus, and he will weigh between 120 and 200 pounds. The Daniff will sport any color of either parent, such as tan, brindle, pied, harlequin, or merle, and it is likely that he will sport the black facial mask.

He will have very big floppy ears, a long muzzle, a square nose, and droopy jowls. This mix is a lot livelier than the Mastiff, and you’ll find him galloping around the backyard, trying to encourage everyone to play with him. He is also very patient, making him a great addition to a family with children.

Irish Mastiff: Irish Wolfhound Mastiff Mix

Mastiff Irish Wolfhound Mix

The Irish Mastiff is the puppy product of the largest and tallest parents around, so you can expect this guy to be one of the biggest mixes on this list. Both the Irish Wolfhound and Mastiff are huge, so for this reason, he is not suited to a small dwelling. However, he is quite a laidback canine, so he shouldn’t be too boisterous in the home. Instead, you’ll likely find him relaxing in the garden or on your lap when possible, so if you are seeking the biggest lap dog known to man, then the Irish Mastiff might just be the one for you. Equally, however, he will protect his family if he feels they are in danger, and he is quite the formidable pooch when he needs to be!

The Irish Mastiff is the tallest on this list, and he will measure a minimum of 30 inches tall and he will weigh a minimum of 120 pounds, so you need to be a strong handler who can invest time into leash training this big pooch. His coat will likely be wiry but brown in color with the black facial mask.

Makita: Mastiff Akita Mix

Akita Mastiff Mix

The Makita is a wonderfully loyal dog who will never leave your side, so if you are seeking a Velcro Mastiff mix, look no further than this guy. The Makita is super affectionate and quite a silly pup with his immediate family, and whilst he can be initially suspicious of strangers, he does eventually warm up to them. However, if he gets a bad feeling about a newcomer, then he jumps into protection mode, but don’t worry, this guy is quite a good judge of character. This is a very popular Akita mix, although less popular when compared to other mastiff mixes.

He will stand between 25 and 30 inches in height and weigh between 85 and 175 pounds. He will have a thick and sturdy body, and his head will likely take after his Akita parent. His coat will be thick and fluffy, so you will have to invest a fair bit of your time grooming him regularly. Ears will be large and triangular shaped, and he might just inherit the distinctive curly tail of the Akita. His coat colors will be entirely dependent on his Akita parent, but it is likely to be a brown shade of some sort, including the brindle option.

Mastador: Mastiff Labrador Retriever Mix

Mastador Mix

The Mastador is one part Mastiff, one part Labrador Retriever, so you know he will be a specially mixed pooch. He is a very sociable and happy guy who loves a good romp around the garden or the local park and will be a lot more active than his Mastiff parent. He is friendly with everyone he meets and especially loves a snooze or two with his family in the evening.

The Mastador is one big boy, he weighs anywhere between 80 to 160 pounds and measures between 23 and 29 inches in height. He tends to look like his Labrador parent but much bigger and broader in stature. He will have large floppy ears and a thick tail that can pack a punch! His coat color will depend on his Labrador parent’s color, but you can expect him to have a black facial mask. For further information on this awesome mix, head over to this article for more Mastador breed information.

Mastahoula: Mastiff Catahoula Leopard Dog Mix

Catahoula Mastiff Mix

The Mastahoula is one of the lesser-known mixes on this list, but one that works just as well as the others. He is a serious pooch by day and will be much happier with a job to do, such as assisting his master on the farm or hunting wild boars, and by night he will happily snuggle up to his master on the sofa and enjoy his well-deserved belly rubs. This pup has a strong prey drive, so be sure to keep this guy on his leash at all times, and you would do well to leash train him from an early age too.  He is very energetic, and he needs to be placed with a family that will either use him as a working dog or one who can guarantee him at least an hour of intense exercise every day.

He will measure between 25 and 29 inches tall and weigh between 75 and 175 pounds. His body is thick and sturdy but more athletic than the Mastiff. His coat will be short and smooth, and he will likely take the brown shading of the Mastiff, with the random merle color splashed across his body. He might also inherit the bright blue or multicolored eyes of the Catahoula, which creates an even more striking-looking pooch.

Mastibull: Mastiff American Pitbull Terrier Mix

Mastiff Pitbull Puppy Mix

The Pit Mastiff is a lot smaller and leaner than the Mastiff, so if you are seeking an athletic-looking dog, then look no further than this guy. He will reach heights of 21 to 27 inches and weigh between 65 and 160 pounds. His coat will be short and smooth, and his coloring will be dependent on his Pitbull parent, but it will likely be a shade of brown.

He is eager to please his master, and because of this, he is quite an obedient and easy-to-train pooch, but just hope he doesn’t inherit his Mastiff parent’s stubbornness! He loves his family, and everyone else for that matter, so don’t expect the best guard dog from the Pit Mastiff. Because he is so sociable, he hates being left alone, so he needs to be placed with a family who can spend a lot of time with him and keep up with his playful character. For further information, take a look at our Mastibull breed profile.

Mastidoodle: Mastiff Poodle Mix


This guy is one of the most unlikely pairings on this list, but given that there is a Doodle version of almost every canine, he was bound to make an appearance. He might inherit the single coat of his hypoallergenic Poodle parent, but it can never be guaranteed. He shouldn’t be treated as a hypoallergenic dog if you or your family have any dog allergies, no matter how much a breeder might try to persuade you otherwise. His coat will be medium length, with a curly kink. It is almost certain that the Mastidoodle will be the product of a Standard Poodle, and therefore you can expect him to measure 18 inches plus, and he will weigh between 70 and 160 pounds.

The Mastidoodle is an energetic pooch who will need to be entertained throughout the day, and it is very likely that he will develop an affinity for water, so reward him with a trip or two to the local lake every week. He is also a very affectionate and kind canine who will very much love the attention he receives from family members and strangers alike.

Mastiff American Bulldog Mix

Mastiff American Bulldog Mix

The Mastiff American Bulldog weighs between 75 and 180 pounds and measures between 23 and 29 inches tall. His coat color will be dependent on his American Bulldog’s coat, but again you can expect that he will inherit the black facial mask. His coat is short and smooth, and you can expect that this guy is going to be a bit of a drooler, considering that both of his parents are. He will have floppy ears that almost look too big for his head which only adds to his charm.

The Mastiff American Bulldog is a protective canine who is suspicious of strangers, but thankfully one who is very obedient and will accept friends into the family circle. He is very affectionate with his family and has a fondness for children, so you’ll often find him snuggling up to your children on the sofa. He is very energetic and boisterous, as such, needs to be placed with a family that can offer him a lot of interactive and vigorous play.

Mastiff Golden Retriever Mix

Golden Mastiff Mix

Like the Mastador, the Mastiff Golden Retriever mix brings in the social & excited nature of the Golden Retriever along with the loyalty and dedication of the Mastiff.  In most Golden Retriever Mastiff mixes you are likely to have a pup slightly smaller than a regular Mastiff and a pup likely to have longer hair. 

The Mastiff Golden Retriever mix will generally be very good family dogs that are slightly larger than a typical Golden and be far less likely to experience the health issues of the larger Mastiff.  This can be a great mix for families that want a larger dog without wanting to train the stubbornness out of a purebred Mastiff.

Mastiff Great Pyrenees Mix

Pyrenees Mastiff Mix

This interesting mix is another breed that’s sure to inherit the size of both parent breeds. The Great Pyrenees is a shepherd dog but is also very good with their families.  Like the English Mastiff, the Pyrenees is larger, with the smaller pups rarely coming in under 80 pounds.  Because the hair on the Pyrenees is long and white, there’s a chance you’ll end up with a pup that has a longer coat with this mix.  It’s likely that you’ll likely want to keep a brush or a tool to manage dog hair around if you adopt this mix, as the Pyrenees are typically notorious shedders.

Mastiff Greyhound Mix

Greyhound Mastiff Mix

This interesting mix brings the gentle giant Mastiff and mixes it with the large, lean, quick-footed Greyhound.  This mix will generally be taller and leaner than the standard English Mastiff and also more athletic.  It will also be less prone to the health issues plaguing the parent breed due to its smaller stature, which is easier on all body parts. This includes the heart, muscles, and joints. 

When Greyhounds aren’t running at the track, they are lapdogs, so you can expect this pup to also be pretty laid back if you welcome them into your home.

Mastiff Husky: Siberian Husky Mastiff Mix

Mastiff Husky Mix

The Stiffsky is a beautiful pooch who will likely inherit the Husky’s bright blue eyes and the Mastiff’s brown coat shades. He will either inherit the Husky’s facial mask or the Mastiff’s and sometimes a combination of both. His coat will be thick and fluffy, and he will need daily grooming just to keep on top of his shedding. He will have large triangular ears, but it is anyone’s guess as to whether they will be floppy or erect. He will measure between 23 and 27 inches in height and will weigh between 65 and 160 pounds.

The Stiffsky is the most energetic on this list, so he needs to be placed with an active family that can guarantee him between 60 and 90 minutes of exercise a day. If he takes after his Husky parent’s size, he would make a great jogging partner, but if he takes after the larger Mastiff, he might not be so eager. He will be very affectionate but also very curious and playful, so he needs to be kept entertained throughout the day because there is not much rest to be had with the Stiffsky.

Mastiff Presa Canario: English Mastiff Presa Canario Mix

Mastiff Presa Canario Mix

The Presa Canario is often mistaken for other molosser breeds, including the Cane Corso or the Pitbull.  When the English Mastiff and Presa Canario are bred as a mix, you’ll end up with a Mastiff-looking pup that will likely end up slightly smaller than the English Mastiff parent.  You’ll still likely have a very large breed on your hands, and this mix can be wary of strangers but very loving with their family. Presas were bred to exterminate wild dogs as pack protectors, so you’ll want to make sure you socialize this breed very early on if you intend to have other pets in the home.

Mastiff Shepherd: German Shepherd Mastiff Mix

Mastiff German Shepherd

The Mastiff Shepherd takes his role as family protector seriously, and it is likely that he will see his main caregiver as his sole master. However, he will be torn between this role and snoozing in the sun all day, so the Mastiff Shepherd can take either temperament. Either way, he is affectionate with his family and energetic, so he will need around one hour of exercise a day to keep him healthy and to keep his intelligent brain occupied.

The Mastiff Shepherd will measure between 24 and 29 inches in height and weigh between 75 and 170 pounds. He will have large ears that may floppy down or stand erect and a long muzzle. His coat will be of medium length, and he will be a moderate shedder throughout the year, and he will sport the colors of either parent, but it is likely that he will be black and tan in color.

Mastiffman: Mastiff Doberman Mix

Doberman Mastiff Mix

The Mastiffman is another great guard dog, and he will be very protective of his family, and for this reason, he can be quite aloof with strangers. But with that being said, many people do not realize how affectionate and gentle the Doberman is with his family, so you can expect the Mastiffman to be seriously soppy with his loved ones. He is also known to be very fond of the smaller members of the family, and he makes a great hot water bottle.  This is a less popular mix than other Doberman mixes, but it’s become more popular over time.

The Mastiffman stands between 25 and 30 inches in height and weighs between 85 and 180 pounds. His coat is short and soft and will take the brown shades with the possibility of a black sheen or markings. His muzzle will be long, his nose square and fleshy, and his big dark eyes and his ears will be large and floppy. He is athletic in appearance but still stocky, and he will have much longer legs than the Mastiff.

Mastifridge: Mastiff Rhodesian Ridgeback Mix

Rhodesian Ridgeback Mastiff Mix

The Mastifridge is a stunning mixed pup who tends to take on an equal mixture of both his parent’s appearances. He is more athletic than the Mastiff but a bit chunkier than the Ridgeback, he will weigh 100 pounds plus and measure between 25 to 29 inches in height. Both of his parents share a similar coat and color, so he can be expected to take a shade of brown with a black facial mask. He will sport those large floppy ears, and he may or may not inherit the distinctive ridge along his spine.

The Mastifridge is a very independent guy, and so you can expect that everything will be done on his timescale, so don’t expect the most obedient of pups here. He is athletic and has a strong prey drive, so you should keep him on a leash at all times and be sure to start leash training as early as possible, or you might just go flying if he spots something tasty. He is a polite pooch who will be affectionate with his family, but he can take or leave attention from strangers.

Mastweiler: Rottweiler Mastiff Mix


The Mastweiler is one of the best guard dogs on this list, so you need to consider this guy if you are seeking a protective canine. That said, both of his parents are big softies at heart, so you can expect this mixed pup to be twice as soft! He loves nothing more than a cuddle after a hard day protecting, and he snores like a bear, so you’ll know when he has signed off for the day.

This big guy measures between 25 and 30 inches in height and weighs between 90 and 190 pounds, so he is one of the heavier mixes on this list. He is a sturdy and heavy-set boy who will knock your ornaments off the table if you are not careful. His coat will be of medium length and soft, and it will likely take the Rottweiler colors but with a light sheen.

Saint Mastiff: Saint Bernard Mix

Saint Bernard Mastiff Mix

This gorgeously large dude is very affectionate, and he loves nothing more than to laze around all day, but just like his Mastiff and Saint Bernard parent, you need to get him moving to keep his large body and ticker healthy. This big fluffy, cuddly bear is a big hit with the little ones, and equally, children are his favored company, so if it is a nanny dog you are seeking, then look no further than the Saint Mastiff. He also has big droopy jowls, just like both of his parents, so you can expect him to share his slobber with you and your furniture.

The Saint Mastiff has a very fluffy coat, and he will shed consistently throughout the year, so you must invest a lot of time into his grooming needs. His coat will take the brown and white colors of both parents, and it is likely that he will inherit the black facial mask of the Mastiff parent. He will stand tall at 28 to 32 inches and weigh between 140 and 200 pounds.

Final Thoughts

Some of these Mastiff mixes are protective, some are silly, and some are so relaxed you will struggle to get them off the sofa, but whichever mixed pup you chose, know that they are all sweet-natured and a pleasure to be around.

You need to ensure that you are prepared for a big pooch, so there needs to be plenty of room, and everyone in the family needs to be able to handle his size. Most mixes will not need an incredible amount of exercise, but this list has a few exceptions if you are after a more active companion. All these guys are sweet souls, and we hope that you have found the gentle giant of your dreams somewhere on this list!

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