What Is Cushing’s Disease In Dogs (Symptoms, Prognosis & Treatment)?

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Dog with cushing's disease on vet tableCushing’s disease is a lifelong, uncommonly cured, condition in dogs. There is treatment to help your dog live more comfortably, but it will not prolong your dog’s life. Find out how you can help your dog live contently with Cushing’s disease.

What Is Cushing’s Disease In Dogs?

Cushing’s disease, also known as hyperadrenocorticism, occurs when the body produces too much cortisol. Cortisol is a hormone produced and stored by the adrenals, which are two small glands that are above the kidneys. Cortisol helps the body during times of stress, regulates appropriate body weight, skin condition and tissue structure. However, too much cortisol can weaken the immune system.

Two Types Of Cushing’s Disease

The type of Cushing’s your dog has determines the treatment prescribed. Blood tests are used to diagnose Cushing’s to help differentiate between the 2 types. An ultrasound may also be used to detect a tumor on an adrenal gland.


80% to 85% of Cushing’s falls within the pituitary-dependent type. This means a tumor triggers it on the pituitary gland at the base of the brain.

The pituitary gland produces hormones including the adrenocorticotropic hormone (ACTH). The tumor causes the pituitary to overproduce ACTH which is then dispersed throughout the bloodstream to the adrenal glands causing them to produce more cortisol.


The remaining 15% to 20% of Cushing’s cases involve a tumor located in one or both adrenal glands causing them to produce excess cortisol.


  • Commonly found in middle-aged to older dogs
  • Drinking more
  • More frequent urination
  • Increased appetite
  • Decrease in activity
  • Excessive panting
  • Fragile skin
  • Hair loss
  • Skin infections
  • Enlarged abdomen (potbellied appearance)


Treating Cushing’s disease in dogs takes careful monitoring and regular checkups with the vet. However, dogs can live a good, happy life if you are responsible with your dog’s care.


Medication is commonly used to help manage the symptoms of both pituitary and adrenal types of Cushing’s disease. Your dog’s vet will schedule regular appointments and conduct blood tests to monitor your dog’s response to treatment. The veterinarian may adjust the dose to help improve your dog’s reaction to medication.

  • Vetoryl (trilostane) is the only drug approved by the FDA to treat both types of Cushing’s. This prescription stops the production of cortisol in the adrenal glands.
  • Anipryl (selegiline) is FDA-approved to treat uncomplicated, pituitary-dependent Cushing’s in dogs.
  • Lysodren (mitotane) is often used to treat dogs with Cushing’s. It is a chemotherapy drug for humans that destroys the layers of the adrenal gland that produce cortisol. This prescription is “off-label,” meaning vets can legally prescribe human drugs to animals and at different dosages than those listed on the label.

Natural Remedies

  • Dandelion is known to normalize adrenal functions1
  • Burdock is good at cleansing unwanted substances from the body1
  • Arsenicum treats excessive thirst1
  • Hepar Sulph heals irritated skin1
  • Sulfur improves skin health1
  • Melatonin hinders 2 enzymes needed to produce cortisol, which reduces cortisol levels2
  • Lignans impede 2 enzymes (different from melatonin) required to produce cortisol, which decreases cortisol levels2

What Is The Recommended Diet For Dogs With Cushing’s?

Ask your vet about the best dog food to give your dog if they have Cushing’s disease.

Is There A Cure?

The only cure for Cushing’s disease is to remove the adrenal tumor if your dog is adrenal-dependant and the cancer hasn’t spread elsewhere. However, this can be difficult and risky, so most cases of Cushing’s disease are treated with medication. Pituitary-dependent dogs do not commonly have surgery because techniques are still under development.


Medication can control small Cushing’s tumors for many years. However, for larger tumors that affect the brain, the prognosis isn’t as good. If your dog has a malignant adrenal tumor, the prognosis is poor. The life expectancy for a dog with pituitary-dependent Cushing’s is 2 years.

What If You Don’t Treat A Dog With Cushing’s Disease?

A dog untreated for Cushing’s disease can live just as long as a dog with treatment. However, the dog without treatment will experience more symptoms; therefore, having a lower quality of life. This is something we suggest discussing with your veterinarian if you are considering treating or not treating your dog’s Cushing’s disease.

When To Put Your Dog With Cushing’s Down

First of all, we’re so sorry you have to consider this. We can’t imagine the pain you are feeling nor how difficult of a decision this is. We recommend speaking with your vet about signs to look for in your dog that may show the time may be approaching.

When the time does come, you may find this article helpful. It discusses grieving the loss of your dog.

Is your dog suffering from Cushing’s Disease? What treatment has helped? 

Sources: [1] Holistic Pet Info, [2] Cushing’s In Dogs, [3] Cushing’s Disease Dogs

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Growing up, Kimberly used to get the sniffles when she was around dogs. Thankfully, she grew out of her allergy and is now able to play and snuggle with dogs as much as she wants! She and her husband adopted Sally, a four-year-old hound mix, in early 2017, and she has brought so much joy into their lives. Life as pet parents has been very rewarding.

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Corlis Vernon
I have two Bichons (12yrs & 11yrs) that have been diagnoised with Cushings,they are both taking Vetoryl, different dosages. Their ALT levels(liver values) are 900 to 1300, they are also taking Ursadiol, for the increased ALT levels. Its sad for us to see them sleeping all the time. We also have another Bichon(14yrs) that has Copper Loading disease, which is bad in itself, ALT is 1700, on multiple meds and more meds to take those meds. We are seeing specialists to manage this, but who helps manage us?
My dog, a Jack Russell, turning 15 this year was diagnosed a few months ago (pituitary). I have tried Vetoryl, but my dog was having adverse reaction to the medication. My dog has a pot belly, excessive thirst, and a huge appetite. Her liver levels are also in the 600 range (she is taking Denamarin for this and it is helping). We are now testing Anipryl 5 mg on her. I have not noticed any difference with one month of treatment. Hopefully, with two months treatment we will notice a difference. Other problems she currently has are a dry nose and a sebaceous growth by her ear.
I was wondering what other treatments has anyone tried that they have seen yield positive results with minor side effects? Has anyone else used Anipryl? I have found the Anipryl to not have any side effects so far, and has actually increased alertness in my dog. She now is back to being at the door when I come home!

Any feedback someone has would be greatly appreciated! Thanks!

My dog a 14 year old 20 lb dachshund was just diagnosed Feb 19, 2019. He too had an adverse reaction to the Vetoryl- he quit eating and he became weak and very lethargic. We stopped the meds. (30mg) for a few days to clear his system and started him back but on the 10 mg. capsule. He got this once a day for two weeks and now we have been giving him it twice a day for a couple of weeks and he is doing awesome! So 20mg per day is apparently what he needed. One 10 mg capsule with breakfast and one 10 mg capsule with dinner. Even his one oozing lumpy growth on his back has stopped oozing! You may want to try lowering the dose :).
My little girl is 13 now and was diagnosed in 2017. She’s no eating much at all not drinking much water. I’m bside myself what to do. She did eat from My hand some dinner chicken we had today. I willContinue to try to feed her. Vet said chicken broth. So I’ll Try again
I had a dog that was a Dachshund Jack Russell since she was a puppy. I just lost her to this disease and she was only 16 of my God I cried for days says I don’t want to let her go but we had to because she was in dippers and couldn’t control her bladder anymore.she was in condeient
So so sorry
How long did she live after she was diagnosed? My Pomeranian was diagnosed 3 years ago and still handling her disease well. She also has a heart murmur. 🙁
Catherine Schure
Are you treating your dog for Cushing s?
Dail Davis
I have a 6yr Old Maltipoo since she was 9 months. She does drink a lot of water and can’t seem to get enough to eat. Her weight is 22# we’ve already spent over 5000$ on her knees years ago. The vet mentioned Cushioning disease. My husband wants me to put her down because now she has torn meniscus and another 2500$ surgery. I don’t know what to do. Need advice
Where did you get your dog nappy’s from to fit a Cushings dog with distended belly?
Amy Bakay
She said her dog was half jack Russell half dachshund. Those are both fairly small types of dog. So, she could have easily gone up a size to fit her dog.
Dail Davis
I have a Maltipoo age 6. She’s always drank a lot of water. But she’s not really pot bellied. After she eats she wants more food. She weighs 22# as of this morning. We’ve spent approximately 2500$ each knee years ago. Now she has a torn meniscus left rear leg and that means another 2500$. I can’t afford the test or the meds if positive for Cushings. He surgery is scheduled for April 3rd. My husband wants me to have her put down. I’m at a lost. She was given to me because of a bad injury I received at work and come near death. An 8 yr old boy told me God told him I needed this dog to help me and it did. Mia is only 6. Am I jumping the gun to even think of putting her down. She has been in continent one time but she could have been dreaming. Need words of encouragement