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8 Great Dane Health Issues You Should Be Aware Of


Last Updated: November 7, 2023 | 7 min read | 21 Comments

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Great Dane looking in field

Great Danes may be a giant breed, but they’re gentle giants. These clumsy, playful dogs can fill a place in your heart and bring you so much joy. Unfortunately, there are some common Great Dane health issues you should know about.

5 Common Health Problems

Great Danes are known for their intelligence, low energy, and guard-like behavior. Unfortunately, this giant breed only averages a lifespan of 6 to 8 years, with an average mature age of 3 years old, so it’s important that you know what health issues may arise so you can help your dog live as long as possible.

1. Gastric Torsion

The most common cause of death for Great Danes is gastric torsion, also known as canine bloat. When humans overeat or eat too fast, we may become bloated and gassy. Fortunately, we can recover quickly from this with minimal discomfort. Dogs are not as lucky, and canine bloat can become life-threatening quickly.

As food passes through a dog’s stomach, gas builds up, and the stomach expands. If the stomach stretches beyond its limits, blood circulation to the heart is prevented, as well as to the stomach. Lack of blood circulation to the stomach results in stomach tissue dying.

The stomach can begin to twist at the top and bottom, which prevents the gas from moving out of the stomach. The stomach experiences extreme damage that is unrepairable. If caught early enough, the dog can receive emergency care to help relieve the gas buildup.

However, it is often difficult to catch bloat early on, and it is often too late to help the dog, which is why it is a common fatal disease. Dogs can die within hours of bloating, so it’s essential to act fast if you think your dog is experiencing it. Because this condition is often fatal, pay attention to any signs of discomfort. Great Dane dying symptoms, in this case, can present quickly and without prior warning. Learn More About Canine Bloat.

Consider a slow-feeder dog bowl or smaller, more frequent meals, as this can slow down eating and reduce the chances of bloat.


  • Differences in normal personality and physical behavior
  • The stomach appears larger, distended, and hard
  • Lack of normal digestive sounds (place your ear on your dog’s stomach and note if there is any difference)
  • Standing in a hunched-over position, unable to get comfortable
  • Refuses to lay on their side
  • Dry heaving, vomiting foam, or mucus
  • Anxious
  • Pacing
  • Whining
  • Licking the air
  • Looking at their abdomen
  • Standing with their legs spread
  • Shallow breathing
  • Weak pulse
  • Collapsing to the ground
  • Cold gums that are dark red (or blue or white in later stages)
  • Attempt to defecate but are unable to


Take your dog to the vet immediately. Depending on how soon you catch the onset of bloat will determine the vet’s course of treatment.

If the stomach is not twisted, your vet may place a small tube down the dog’s throat (while they are sedated) to help gas be removed from the stomach.

If the stomach is twisted, surgery will most likely take place, and the vet will make an incision into the dog’s stomach to relieve gas pressure. The vet may also staple your dog’s stomach in place so that if this occurs again, the stomach cannot expand.

After either course of treatment, your dog should undergo a complete physical to make sure no severe damage occurs. Stomach tissue may need to be removed to preserve the stomach’s function. Your vet may recommend having an anti-gas medication on hand for your dog.

2. Hip Dysplasia

Hip dysplasia often manifests itself in larger dog breeds, and Great Danes fit the bill. Sadly, hip dysplasia is a chronic condition in which the head of the femur bone doesn’t fit into the hip socket correctly. If you adopt a Great Dane from a breeder, ask for radiographs of the parents’ hips and speak to them about the parents’ health history. Learn More About Hip Dysplasia.


  • Pain or discomfort during exercise
  • Lameness
  • Stiff back legs
  • “Bunny hop” like run
  • Stiffness getting up or running
  • Difficulty getting up
  • Muscle tone loss in back legs
  • Lack of enjoyment with physical activities that were previously enjoyable


Your vet will probably do an x-ray to view the dog’s hip sockets and make an appropriate diagnosis with a treatment plan.

3. Dilated Cardiomyopathy (DCM)

Dilated cardiomyopathy causes the heart to enlarge and is most likely genetic. It is a very serious condition that often does not get diagnosed until it is too late to help. There are some treatment options, but DCM has no cure.


Unfortunately, cardiomyopathy commonly goes undiagnosed until the dog dies. However, if you notice any of the symptoms below, take them to the vet immediately.

  • Lethargy
  • Weight loss
  • Weakness
  • Coughing
  • Increased heart rate
  • Difficult breathing
  • Abdominal distension
  • Difficulty exercising
  • Decreased appetite
  • Less happy and more depressed


Several drugs are used to treat the symptoms of dilated cardiomyopathy (DCM).

  • Diuretics – remove excess fluid from the body
  • Angiotensin-converting enzyme inhibitors – lower blood pressure
  • Cardiac glycosides – slow heart rate and strengthen heart contractions
  • Vasodilators – dilate the arteries and veins so the heart doesn’t have to work as hard
  • Bronchodilators – help a dog with DCM breathe easier
  • Pimobendan – lowers the pressure in arteries and veins and improves the heart muscle strength
  • Antiarrhythmic drugs – help control arrhythmias

4. Tricuspid Valve Disease

Tricuspid valve disease is a congenital condition where the heart valve doesn’t function correctly. As a result, the left side of your dog’s heart may fail.


  • Distended stomach
  • Decrease in exercise ability
  • Difficulty breathing
  • Heart murmur
  • Increased heartbeat
  • Weakness


If there is a large amount of fluid in the dog’s heart, the vet may remove some fluid. The dog will probably be placed on a low-salt diet, and overweight dogs will be encouraged to lose weight. Moderate activity is okay, but your dog should avoid exertion.

The vet may suggest some supplements and vitamins, such as:

  • Vitamin D
  • Coenzyme CoQ10
  • Omega 3

Other medications that may be prescribed include:

  • Digoxin
  • Furosemide
  • Angiotensin enzyme inhibitor

These treatments can improve your dog’s quality of life. If they are not responding to treatment, your vet may refer them to a cardiac vet specialist, and surgery may be considered to replace the valve.

5. Cancer

Osteosarcoma, or bone cancer, is commonly diagnosed in Great Danes. Great Danes are also at high risk for other cancers, including lymphosarcoma, hemangiosarcoma, and mast cell tumors. Pay attention to small and large bumps under the skin, unexplained odors, and weight loss, as these are all early signs of cancer in dogs.


  • Lumps in various parts of the body
  • Swelling
  • Lameness
  • Joint or bone pain
  • Tired
  • Anorexia


Depends on the stage of the disease, the dog’s age, etc. Your vet will talk with you about a course of treatment for your dog.

Do Not Forget Great Dane Skin Problems

Great Danes are also prone to skin problems, including allergies. In Great Danes, allergies to environmental elements like dust, pollen, mold, and food are common. These allergies cause itchy skin, called atopy. It often affects the folds of skin, feet, ears, and belly but can cause itchy skin anywhere. Great Danes’ skin problems can lead to infection on the paws, which is extremely painful. Your dog may need allergy treatment to prevent skin issues.

3 Common Pet Insurance Claims Filed With Fetch

According to Fetch, Great Danes are also commonly treated for the following conditions.

1. Addison’s Disease

Also known as hypoadrenocorticism, Addison’s disease forms from the decrease in corticosteroid secretion from the adrenal gland. (If there was an increase of this hormone, your dog may have Cushing’s disease.) Fetch averages a claim of $1,287 for Addison’s disease.


  • Common in young to middle-aged female dogs
  • Lethargy
  • Anorexia
  • Vomiting
  • Muscle weakness


The most common treatment is replacing the mineralocorticoids and glucocorticoids in the body. Florinef is commonly prescribed and given twice per day.

Blood sodium and potassium levels are monitored to determine the correct dose for the dog. After the dog is regulated, the levels are reached 2 to 30 times per year, and adjustments are made as necessary.

Another treatment option is an injection of DOCP, which is administered every 25 days. It is known to regulate better than Florinef. Prednisone may also be prescribed to your dog in conjunction with DOCP.

2. Wobbler Syndrome

Also known as cervical spondylomyelopathy (CSM), wobbler syndrome affects the cervical spine at the neck and is common in large breeds. The term wobbler syndrome comes from the wobbly walk that presents itself in dogs who have it. Fetch claims for wobbler syndrome average $3,866.


  • Wobbly gait
  • Stiff neck
  • Weakness
  • Shorter stride
  • Weak front limbs
  • Partial or complete paralysis
  • Muscle loss near the shoulders
  • Scuffed nails from uneven walking
  • Difficulty getting up


Depending on the severity and location of the spinal compression, your vet may or may not recommend surgery. Your dog may be put on bed rest and need to be moved to their other side every 4 hours to prevent bed sores. A catheter may be inserted to allow the dog to rest.

If medically treated, activity may be restricted for more than 2 months. Surgery is commonly looked at as the best option, but there are complications that you should ask your veterinarian about. Physical therapy will most likely be suggested for post-op dogs to avoid further damage and to help them recover.

3. Cruciate Ligament Tears

Fetch claims are an average of $3,543 for cranial cruciate ligament (CCL) tears. CCL tears are the equivalent of ACL tears in humans. Cruciate ligaments are found in the hind legs of dogs and may be partial or complete tears.


  • Limping in hind legs
  • Awkward posture standing, sitting, or lying down
  • Difficulty getting up
  • Swelling around the knee


Treatment often entails surgery, which can be rather expensive if you don’t have pet insuranceLearn More About CCL Tears.

Best Pet Insurance For Great Danes

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We know you’ll always do what you think is best for your dog and care for them as you see fit. However, are you looking out for your wallet when pet emergencies arise? Those claim amounts weren’t anything to shrug off.

Unfortunately, pet parents are often faced with the difficult decision of choosing to treat their dog and pay for an expensive vet bill, not getting the dog help because the costs are too high. In extreme cases, pet parents even decide to euthanize their best friend because they can’t afford treatment. This is a situation we’ve heard of too many times, and it breaks our hearts that parents are faced with it.

That’s why we recommend pet insurance, so when your dog is hurt and needs medical attention, your bank account isn’t the deciding factor. You might be surprised to learn that the average pet insurance policy is less than $50/month. Some are even less than $30/month, depending on the coverage options you choose. You can read reviews of pet insurance companies and get an idea of how much it might cost you by reading our pet insurance reviews.

The information provided through this website should not be used to diagnose or treat a health problem or disease; it is not intended to offer any legal opinion or advice or a substitute for professional safety advice or professional care. Please consult your health care provider, attorney, or product manual for professional advice. Products and services reviewed are provided by third parties; we are not responsible in any way for them, nor do we guarantee their functionality, utility, safety, or reliability. Our content is for educational purposes only.

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